台湾女优

个人简介

遗传学与生物医学信息学系副教授、硕士生导师

广东省青年珠江学者

中山大学逸仙学者计划“新锐学者”

中山大学百人计划青年学术骨干

个人履历

2022-至今台湾女优-台湾女优av 副教授

2017-2022 美国宾夕法尼亚大学医学院/费城儿童医院博士后

2016-2017 美国哥伦比亚大学医学院博士后

2010-2015 北京大学基础医学院博士

2006-2010 中国药科大学药学院本科

研究方向

1）遗传变异的检测和解读的新算法；

2）医学人工智能/自然语言处理。

讲授课程

本科：《生物信息学》、《医学信息技术基础》

研究生：《人工智能基础与应用》、《生物信息学编程》、《生物信息学》、《基因组与蛋白质组学技术》

培养研究生

在读：王瑞涵、李嘉璐、陈易枫

毕业：蔡文灏

个人主页

//fanglab.cn

热忱欢迎有志于医学遗传学、生物信息学、医学人工智能和自然语言处理研究的同学加入，有意者请联系：[email protected]

代表性论著

1. Yang R, Zhu J, Man J, Liu H, Fang L#, Zhou Y.# GS-KGC: A generative subgraph-based framework for knowledge graph completion with large language models. Information Fusion. 2025 May;117:102868. (#corresponding authors, IF: 14.7，中科院1区Top，中国人工智能学会推荐A类)
2. Yang R, Zhu J, Man J, Fang L#, Zhou Y#. Enhancing text-based knowledge graph completion with zero-shot large language models: A focus on semantic enhancement. Knowledge-Based Systems. 2024 Sep;300:112155. (#corresponding authors, IF: 7.2，中科院1区Top)
3. Jiang T, Fang L#, Wang K#. Deciphering the Language of Nature: A transformer-based language model for deleterious mutations in proteins. The Innovation. 2023. DOI: //doi.org/10.1016/j.xinn.2023.100487 (#corresponding authors, IF: 32.1，中科院1区Top)
4. Ahsan MU, Liu Q, Perdomo JE, Fang L, Wang K. A survey of algorithms for the detection of genomic structural variants from long-read sequencing data. Nature Methods. 2023. DOI: //doi.org/10.1038/s41592-023-01932-w (IF: 48.0，中科院1区Top)
5. Fang L*, Monteys AM*, Dürr A, Keiser M, Cheng C, Harapanahalli A, et al. Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing. Human Genetics and Genomics Advances. 2023. DOI: //doi.org/10.1016/j.xhgg.2022.1001466 (*co-first author)
6. Fang L, Wang K. Polishing high-quality genome assemblies. Nature Methods. 2022. DOI: //doi.org/10.1038/s41592-022-01515-1 (IF: 48.0，中科院1区Top)
7. Fang L*, Liu Q*, Monteys AM, Gonzalez-Alegre P, Davidson BL, Wang K. DeepRepeat: direct quantification of short tandem repeats on signal data from nanopore sequencing. Genome Biology. 2022. DOI: //doi.org/10.1186/s13059-022-02670-6 (*co-first author, IF: 17.9，中科院1区Top)
8. Fang L, Kao C, Gonzalez MV, Mafra FA, Pellegrino da Silva R, Li M, et al. LinkedSV for detection of mosaic structural variants from linked-read exome and genome sequencing data. Nature Communications. 2019. DOI: //doi.org/10.1038/s41467-019-13397-7 (IF: 17.7，中科院1区Top)
9. Zhao M*, Havrilla JM*, Fang L*, Chen Y, Peng J, Liu C, Wu C, Sarmady M, Botas P, Isla J, Lyon GJ, Weng C, Wang K. Phen2Gene: rapid phenotype-driven gene prioritization for rare diseases. NAR Genomics and Bioinformatics. 2020. DOI: //doi.org/10.1093/nargab/lqaa032 (*co-first author)
10. Fang L, Wang K. Identification of Copy Number Variants from SNP Arrays Using PennCNV. Methods in Molecular Biology. 2018. DOI: //doi.org/10.1007/978-1-4939-8666-8_1 (Springer book series)
11. Yang H, Luan Y, Liu T, Lee HJ, Fang L, Wang Y, et al. A map of cis-regulatory elements and 3D genome structures in zebrafish. Nature. 2020 Dec 10;588(7837):337–43.